✦ LIBER ✦

Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: A role for free radicals, NFκB, and TNFα

✍ Scribed by Alexander Soloviev; Edward M. Schwarz; Michael Darowish; Regis J. O’Keefe

Book ID: 113834660
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 348 KB
Volume: 23
Category: Article
ISSN: 0736-0266
DOI: 10.1016/j.orthres.2005.03.019

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Sphingomyelinase mediates macrophage act

Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: A role for free radicals, NFkB, and TNFα

✍ Alexander Soloviev; Edward M. Schwarz; Michael Darowish; Regis J. O'Keefe 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 835 KB

The manner in which wear debris initiates intracellular signaling and macrophage activation remains poorly understood. While particle phagocytosis has been implicated in this process, recent studies have shown that phagocytosis is not required for macrophage activation. We examined the hypothesis th

Induction of TNFα in macrophages by vana

Induction of TNFα in macrophages by vanadate is dependent on activation of transcription factor NF-κB and free radical reactions

✍ Jianping Ye; Ming Ding; Xiaoying Zhang; Yon Rojanasakul; Sergei Nedospasov; Val 📂 Article 📅 1999 🏛 Springer 🌐 English ⚖ 71 KB

Stimulation of macrophage TNFα productio

Stimulation of macrophage TNFα production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-κB pathways but is independent of p38 and JNK

✍ Michelle A. Beidelschies; Honglian Huang; Megan R. McMullen; Matthew V. Smith; A 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 608 KB

## Abstract Bone loss that causes aseptic loosening of orthopedic implants is initiated by pro‐inflammatory cytokines produced by macrophages in response to implant‐derived wear particles. MAPK and NF‐κB signaling pathways are activated by the particles; however, it is not clear which of the signal