Activation of myosin heavy chain genes during cardiac hypertrophy
β Scribed by N. Selvamurugan; J. Kamala; C. Rajamanickam
- Book ID
- 112830238
- Publisher
- Indian Academy of Sciences
- Year
- 1988
- Tongue
- English
- Weight
- 873 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0250-5991
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The β£and β€-myosin genes extend over 51 kb on chromosome 14 in human and 11 in mouse separated by about 4.5 kb of intergenic sequence. They are located in tandem in the order of their expression during development. Transcription of each gene is independently controlled but coordinately regulated. Dur
We have recently determined the complete nucleotide sequences of the cardiac alpha- and beta-myosin heavy chain (MyHC) genes from both human and Syrian hamster. These genomic sequence data were used to study the molecular evolution of the cardiac MyHC genes. Between the alpha- and beta-MyHC genes, m