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Concerted evolution of mammalian cardiac myosin heavy chain genes

✍ Scribed by Trevor A. Epp; Ruoxiang Wang; Michael J. Sole; Choong-Chin Liew


Publisher
Springer
Year
1995
Tongue
English
Weight
814 KB
Volume
41
Category
Article
ISSN
0022-2844

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Concerted evolution of mammalian cardiac
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We have recently determined the complete nucleotide sequences of the cardiac alpha- and beta-myosin heavy chain (MyHC) genes from both human and Syrian hamster. These genomic sequence data were used to study the molecular evolution of the cardiac MyHC genes. Between the alpha- and beta-MyHC genes, m

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Several neuroendocrine factors have been shown to influence the muscle phenotype. Various physiological reports have suggested the role of adrenergic nervous system for cardiac myosin heavy chain (MHC) expression. We have used cultured fetal rat heart myocytes to investigate the role of cAMP on the