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Activation of latent TGF-beta-1 by plasmin: Physiological regulation of growth factor activity

โœ Scribed by Safo, Yasufumi; Rifkin, Daniel B.


Book ID
123037277
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
138 KB
Volume
3
Category
Article
ISSN
0268-9499

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Cultured human melanoma cells were found to secrete TGF-P mostly in latent biologically inactive form but in addition five of six melanoma cell lines studied produced in conditioned culture medium active TGF-p in the range from 370 to 61 0 pg per 1 O6 cells per 24 h. A distinct characteristic of the