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Activation of EGFR by proteasome inhibition requires HB-EGF in pancreatic cancer cells

✍ Scribed by Sloss, C M; Wang, F; Palladino, M A; Cusack, J C


Book ID
109972647
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
489 KB
Volume
29
Category
Article
ISSN
0950-9232

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## Abstract In this study, we demonstrated that tyrosine phosphorylation of EGFR and the autocrine expression of uPA and HB‐EGF depend on the activity of c‐jun amino‐terminal kinase (JNK) in human prostatic DU‐145 cells. These cells overexpress EGFR and produce a high amount of uPA. Treatment with