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Activation of dendritic cells and induction of CD4+ T cell differentiation by aluminum-containing adjuvants

✍ Scribed by Anna Sokolovska; Stanley L. Hem; Harm HogenEsch

Book ID
116959726
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
724 KB
Volume
25
Category
Article
ISSN
0264-410X

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Dendritic cells (DCs) secrete vesicles of endosomal origin, called exosomes, that bear major histocompatibility complex (MHC) and T cell costimulatory molecules. Here, we found that injection of antigen- or peptide-bearing exosomes induced antigen-specific naïve CD4+ T cell activation in vivo. In vi