Activation of Cellular Oncogenes by Chemical Carcinogens in Syrian Hamster Embryo Fibroblasts
✍ Scribed by Rolf Ebert, J. Carl Barrett, Roger W. Wiseman, Reinhard Pechan, Eva Reiss, Günther Röllich and Dietmar Schiffmann
- Book ID
- 124295555
- Publisher
- Environmental Health Information Service
- Year
- 1990
- Tongue
- English
- Weight
- 540 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0091-6765
- DOI
- 10.2307/3431070
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The Syrian hamster embryo (SHE) cell transformation model has been used by many investigators to study the multistep process of neoplastic transformation induced by chemical carcinogens. In this study we have attempted to determine if activated proto-oncogenes are present in the transformed cells in
## Abstract The production of the extracellular protease, plas‐minogen activator, in relationship to growth in semi‐solid medium and tumorigenicity has been studied in Syrian hamster embryo and strain 2 guinea‐pig embryo cell culture models of chemical carcinogenesis. Whereas normal hamster and gui