Receptor-mediated calcium entry was investigated in Fura 2 loaded FRTL-5 cells. The purinergic agonist ATP activated the release of sequestered calcium and the entry of extracellular calcium. Downregulation of protein kinase C (PKC) substantially enhanced the ATP-evoked calcium entry. Pretreatment o
Activation of calcium entry by cyclopiazonic acid in thyroid FRTL-5 cells
✍ Scribed by K. Törnquist
- Book ID
- 113236629
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 604 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0143-4160
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📜 SIMILAR VOLUMES
Stimulating rat thyroid FRTL-5 cells with agonists that activate the inositol phosphate cascade results in the release of sequestered calcium and influx of extracellular calcium. In addition, phospholipase A, (PLA,) is activated. Since PLA, is a calcium-dependent enzyme we wanted to investigate the
The aim of the present study was to investigate the relationship between agonist-induced changes in intracellular free CaL+ ([Ca"],) and the refilling of intracellular CaLc stores in Fura 2-loaded thyroid FRTL-5 cells. Stimulating the cells with ATP induced a dose-dependent increase in ([Gal-' 1,).