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Activation of Bak in ultrasound-induced, JNK- and p38-independent apoptosis and its inhibition by Bcl-2

✍ Scribed by Manabu Kinoshita; Yutaka Eguchi; Kullervo Hynynen

Book ID: 116294123
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 666 KB
Volume: 353
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2006.12.055

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## Abstract Androgen‐independent prostate cancers express high levels of Bcl‐2, and this over‐expression of Bcl‐2 protects prostate cancer cells from undergoing apoptosis. Ursolic acid (UA) has demonstrated an anti‐proliferative effect in various tumor types. The aim of this study is to evaluate th