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Activation of androgen receptor in epidermal growth factor modulation of fetal mouse sexual differentiation

โœ Scribed by Chhanda Gupta; Aarti Chandorkar; Aline P. Nguyen


Book ID
116122845
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
864 KB
Volume
123
Category
Article
ISSN
0303-7207

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Incubation of Swiss mouse 3T3 cells at 37ยฐC with bovine brain-derived growth factor (BDGF) decreased the cell surface '251-EGF binding activity of these cells by 70-80%. This down-modulation of the EGF receptor by BDGF was time, temperature, and dose dependent. Scatchard plot analysis indicated that