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Activation of a Nonclassical NKT Cell Subset in a Transgenic Mouse Model of Hepatitis B Virus Infection

โœ Scribed by Jody L Baron; Leon Gardiner; Stephen Nishimura; Kanade Shinkai; Richard Locksley; Don Ganem


Book ID
117723215
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
468 KB
Volume
16
Category
Article
ISSN
1074-7613

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To develop synthetic short interfering RNA (siRNA) molecules as therapeutic agents for systemic administration in vivo, chemical modifications were introduced into siRNAs targeted to conserved sites in hepatitis B virus (HBV) RNA. These modifications conferred significantly prolonged stability in hu