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A mouse-human chimeric model for infection and replication of hepatitis virus B in vivo

✍ Scribed by Brown, JJ; Parashar, B; Rabani, E; Englhardt, D; Moshage, H; Roy Chowdhury, N; Roy Chowdhury, J


Book ID
123214755
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
169 KB
Volume
114
Category
Article
ISSN
0016-5085

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Studies of hepatitis B virus (HBV) mutants have been hampered by the lack of a small animal model with long-term infection of cloned HBV. Using a mouse model in which liver cells were highly replaced with human hepatocytes that survived over a long time with mature human hepatocyte function, we perf