Mutation analysis of the N-ras proto-onc
Mutation analysis of the N-ras proto-oncogene in active and remission phase of human acute leukemias
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H.-P. Senn; Ch. Trวn-Thang; A. Wodnar-Filipowicz; J. Jiricny; M. Fopp; A. Gratwo
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Article
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1988
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John Wiley and Sons
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French
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DNA isolated from blood or bone-marrow samples from 18 patients with acute non-lymphocytic leukemia (ANLL) and 14 patients with acute lymphocytic leukemia (ALL) was analyzed for the presence of mutations in the N-ras gene. Using synthetic oligonucleotide probes we detected mutations in 5 cases of AN