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Activation-independent nuclear translocation of mitogen activated protein kinase ERK1 mediated by thiol-modifying chemicals

✍ Scribed by Ruedi Meili; Kurt Ballmer-Hofer


Book ID
115932854
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
496 KB
Volume
394
Category
Article
ISSN
0014-5793

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The observation that mitogen-activated protein (MAP) kinases ERK1 and ERK2 are constitutively activated in a number of oncogene-transformed cell lines has led to the hypothesis that prolonged activation of these enzymes is required for the transformation process. To investigate this question, we hav