Granulocyte colony stimulating factor (G-CSF) regulates survival, proliferation, differentiation, and activation of myeloid cells. It binds to a high affinity receptor (G-CSF-R) expressed on myeloid cells, for which the signal transduction mechanisms other than protein tyrosine kinase (PTK) activati
Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C
β Scribed by Makoto Sawada; Akio Suzumura; Hiroko Yamamoto; Tohru Marunouchi
- Book ID
- 115800380
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 952 KB
- Volume
- 509
- Category
- Article
- ISSN
- 0006-8993
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## Abstract Previously, we suggested that the phosphatidylinositol 3βkinase (PI3K)βp70 S6 kinase (p70 S6K) pathway plays an important role in granulocyte colonyβstimulating factor (GβCSF)βdependent enhancement of the neutrophilic differentiation and proliferation of HLβ60 cells. While atypical prot