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Activation and nuclear translocation of PKCδ, Pyk2 and ERK1/2 by gonadotropin releasing hormone in HEK293 cells

✍ Scribed by Parvaiz Q Farshori; Bukhtiar H Shah; Krishan K Arora; Antonio Martinez-Fuentes; Kevin J Catt


Book ID
117668577
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
436 KB
Volume
85
Category
Article
ISSN
0960-0760

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## Abstract Bradykinin (BK) and angiotensin II (AngII) often have opposite roles in cardiovascular diseases. Our aim here was to construct hybrid receptors which bind AngII but signal as BK. Various sequences of the intracellular face of the AngII type I receptor, AT1R, were replaced with correspon