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Activation and inhibition of the proteasome by betulinic acid and its derivatives

✍ Scribed by Li Huang; Phong Ho; Chin-Ho Chen


Book ID
118255784
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
525 KB
Volume
581
Category
Article
ISSN
0014-5793

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New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at