## Background: This retrospective study evaluated the benefit of using tumor necrosis factor (tnf) and melphalan administered via an isolated limb perfusion (ilp) in a series of patients with metastatic melanoma who failed initial ilp with chemotherapeutics. ## Methods: Seventeen patients with ex
Activation and inhibition of the fibrinolytic system in cancer patients after isolated limb perfusion with tumor necrosis factor a, (interferon γ) and melphalan
✍ Scribed by V.J.J. Bom; J.H. Zwaveling; A.R.J. Girbes; R.J. van Ginkel; H.Schraffordt Koops; J. van der Meer
- Book ID
- 119154635
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 138 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0268-9499
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## Background: Isolated limb perfusion (ilp) with tumor necrosis factor alpha (tnf alpha) +/-interferon gamma (ifn gamma) and melphalan in patients with primarily irresectable soft tissue sarcoma is promising in terms of tumor regression and limb salvage. however, the feasibility of radiotherapy in
## Abstract ## BACKGROUND Since 1992, isolated limb perfusion (ILP) with tumor necrosis factor‐α (TNFα) and melphalan has been used for the treatment of patients with unresectable soft tissue sarcomas of the extremities. The authors retrospectively studied the results of limb salvage surgery using