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Activation and fragmentation of the third (C3) and the fourth (C4) components of complement: Generation and isolation of physiologically relevant fragments C3c and C4c

โœ Scribed by Jarmila Janatova; R.Joseph Gobel


Book ID
118899914
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
664 KB
Volume
85
Category
Article
ISSN
0022-1759

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โœ M. Andersson; A. Hanson; G. Englund; B. Dahlbรคck ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Springer ๐ŸŒ English โš– 537 KB

The effect of cadralazine and its active metabolite CGP 22639 on the covalent binding reaction of C4 and C3 has been studied. Trypsin-Sepharose was used to activate radio-labelled C3 and C4 and binding of the radio-labelled protein to the trypsin-Sepharose was measured. Cadralazine inhibited 50% of