In polycythemia Vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%. This risk has been estimated to be 1-5.9% with hydroxyurea (HU) therapy. When compared with historical controls, the risk with use of HU does not a
✦ LIBER ✦
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
✍ Scribed by Ross L. Levine; Martha Wadleigh; Jan Cools; Benjamin L. Ebert; Gerlinde Wernig; Brian J.P. Huntly; Titus J. Boggon; Iwona Wlodarska; Jennifer J. Clark; Sandra Moore; Jennifer Adelsperger; Sumin Koo; Jeffrey C. Lee; Stacey Gabriel; Thomas Mercher; Alan D’Andrea; Stefan Fröhling; Konstanze Döhner; Peter Marynen; Peter Vandenberghe; Ruben A. Mesa; Ayalew Tefferi; James D. Griffin; Michael J. Eck; William R. Sellers; Matthew Meyerson; Todd R. Golub; Stephanie J. Lee; D. Gary Gilliland
- Book ID
- 113523550
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 459 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1535-6108
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