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The JAK2V617F tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates

✍ Scribed by Ayalew Tefferi; Terra L. Lasho; Susan M. Schwager; David P. Steensma; Ruben A. Mesa; Chin-Yang Li; Martha Wadleigh; D. Gary Gilliland


Book ID
108673460
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
116 KB
Volume
131
Category
Article
ISSN
0007-1048

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Correlations of JAK2–V617F mutation with
✍ Matthaios Speletas; Eirini Katodritou; Chrisoula Daiou; Eudokia Mandala; Emmanou πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 212 KB

Recently, the acquired mutation JAK2-V617F has been described in the majority of patients with myeloproliferative disorders (MPDs). In this study we evaluated its clinical and laboratory correlates in 166 patients with MPDs. The mutation was detected by allele-specific PCR in 119 patients: 81.4% (35