Activated nitriles in heterocyclic synthesis: Novel Synthesis of Pyrimidine and of Pyridine Derivatives
β Scribed by Dr. Zaghloul El-Shahat Kandeel; Dr. Khalid Mohamed Hassan; Dr. Nabila Ahmed Ismail; Prof. Dr. Mohamed Hilmy Elnagdi
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 251 KB
- Volume
- 326
- Category
- Article
- ISSN
- 1615-4150
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## Abstract A new route for the synthesis of 3Hβ1,2,4βtriazolo[1,5βa]pyridines 7aβj, 12a,b, and 17a,b utilizing the reaction of the hydrazones of cyanoethanoic acid hydrazide 3a,b with ylidene malononitriles 2aβe, malononitrile, and 3βaminocrotononitrile is described.
## A simple route to the synthesis of the pharmaceutically important thieno[2,3-d]pyrimidine derivatives and of thieno[2,3-b]pyridine derivatives via the use of 5-amin0-3-phenylthiophene-2,Cdicarbonitrile (2) as a starting material is described.