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Activatable imaging probes with amplified fluorescent signals

✍ Scribed by Lee, Seulki; Park, Kyeongsoon; Kim, Kwangmeyung; Choi, Kuiwon; Kwon, Ick Chan

Book ID
111926042
Publisher
Royal Society of Chemistry
Year
2008
Tongue
English
Weight
470 KB
Volume
36
Category
Article
ISSN
1359-7345

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Figure 3. Fluorescence imaging of subcutaneous IGROV1 tumour-bearing mice, 10 min and 5 h after IV injection of the probes (dissolved in PBS 10 mm, pH 7.4, with 10 % DMSO, 10 % EtOH), at 10 nmol Cy5 per mouse. The images are acquired and presented with the same camera settings, with the fluorescence

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## Abstract __In vivo__ optical imaging using fluorescently labeled self‐quenched monoclonal antibodies, activated through binding and internalization within target cells, results in excellent target‐to‐background ratios. We hypothesized that these molecular probes could be utilized to accurately r