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Activatable probes for non-invasive small animal fluorescence imaging

✍ Scribed by Isabelle Texier; Jésus Razkin; Véronique Josserand; Didier Boturyn; Pascal Dumy; Jean-Luc Coll; Philippe Rizo

Book ID
103856109
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
348 KB
Volume
571
Category
Article
ISSN
0168-9002

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✦ Synopsis

Fluorescence tomography today appears as a complementary imaging modality for assessing molecular processes in small living animals. A new design of fluorescent activatable units for the imaging of cellular internalization of probes is proposed. Disulfide bridges are used as intracellular cleavable bounds for fluorescence activation. These units are not activated in blood, neither in vitro nor in mouse, but specifically in the presence of lysed cells or a chemical reducer. We therefore expect that the use of such activatable units, grafted to targeting moieties, will improve significantly the contrast of images obtained in the future.

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