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Action of phorbol esters in cell culture: Mimicry of transformation, altered differentiation, and effects on cell membranes

✍ Scribed by Weinstein, I. Bernard ;Lee, Lih-Syng ;Fisher, Paul B. ;Mufson, Alan ;Yamasaki, Hiroshi

Publisher: Wiley (John Wiley & Sons)
Year: 1979
Tongue: English
Weight: 946 KB
Volume: 12
Category: Article
ISSN: 0091-7419
DOI: 10.1002/jss.400120206

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✦ Synopsis

Weinstein et a1

and cellular effects of initiating carcinogens and tumor promoters is presented. According to this model, initiating carcinogens induce stable alterations in the cellular genome but these are not manifested until tumor promoters modulate programs of gene expression and induce the clonal outgrowth of the initiated cell.

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