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Action of BTN1, the yeast orthologue of the gene mutated in Batten disease

✍ Scribed by Pearce, David A.; Ferea, Tracy; Nosel, Seth A.; Das, Biswadip; Sherman, Fred

Book ID
109831693
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
284 KB
Volume
22
Category
Article
ISSN
1061-4036

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The Saccharomyces cerevisiae gene BTN1, encodes a 408 amino acid putative integral membrane protein, which is 39% identical and 59% similar to the human Cln3p, whose mutant forms are responsible for Batten's disease and for a diminished degradation of mitochondrial ATPase synthase subunit c. Disrupt