✦ LIBER ✦
BTN1, a Yeast Gene Corresponding to the Human Gene Responsible for Batten's Disease, is Not Essential for Viability, Mitochondrial Function, or Degradation of Mitochondrial ATP Synthase
✍ Scribed by PEARCE, DAVID A.; SHERMAN, FRED
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 142 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0749-503X
No coin nor oath required. For personal study only.
✦ Synopsis
The Saccharomyces cerevisiae gene BTN1, encodes a 408 amino acid putative integral membrane protein, which is 39% identical and 59% similar to the human Cln3p, whose mutant forms are responsible for Batten's disease and for a diminished degradation of mitochondrial ATPase synthase subunit c. Disruption experiments established that Btn1p is not essential for viability, mitochondrial function, or degradation of mitochondrial ATP synthase in yeast.