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Actinomycin D Binds Strongly to d(CGACGACG) and d(CGTCGTCG)

✍ Scribed by Sha, Feng; Chen, Fu-Ming


Book ID
118513641
Publisher
Biophysical Society
Year
2000
Tongue
English
Weight
159 KB
Volume
79
Category
Article
ISSN
0006-3495

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## Abstract Actinomycin D is an anticancer antibiotic best know for inhibiting transcription by binding double‐stranded DNA. Tight, sequence selective binding of actinomycin to single‐stranded DNA is also known, however, and is implicated in biological activities including inhibition of (βˆ’) strand