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Acrylamide catalytically inhibits topoisomerase II in V79 cells

โœ Scribed by Giulia Sciandrello; Maurizio Mauro; Fabio Caradonna; Irene Catanzaro; Marghereth Saverini; Giusi Barbata

Book ID
116920189
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
610 KB
Volume
24
Category
Article
ISSN
0887-2333

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โœ Ronald D. Snyder ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 117 KB

Determination of the clastogenic potential of new chemical entities, particularly pharmaceuticals, is an important part of the overall safety assessment of such drugs. It is appreciated that clastogenicity can arise from perturbation of many different cellular processes distinct from direct DNA/drug