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Acquisition of regulatory function by human CD8+ T cells treated with anti-CD3 antibody requires TNF

✍ Scribed by Vitaly Ablamunits; Brygida Bisikirska; Kevan C. Herold

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
530 KB
Volume
40
Category
Article
ISSN
0014-2980

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## Abstract Treatment with anti‐CD3 mAb modulates immune responses that cause type 1 diabetes and other diseases. CD8^+^ Tregs can be induced in vitro and in vivo by mAb. However, 1/3 of patients do not respond to drug therapy and in an equal proportion, anti‐CD3 mAb does not induce Tregs in vitro.