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Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia

โœ Scribed by Tack, Jan; Janssen, Pieter

Book ID
120991625
Publisher
Informa plc
Year
2011
Tongue
English
Weight
568 KB
Volume
20
Category
Article
ISSN
1354-3784

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Mechanism for distribution of acotiamide
Mechanism for distribution of acotiamide, a novel gastroprokinetic agent for the treatment of functional dyspepsia, in rat stomach
โœ Kazuyoshi Yoshii; Masamichi Hirayama; Toshifumi Nakamura; Ryoko Toda; Junko Hase ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 280 KB

The novel gastroprokinetic agent acotiamide improves gastric motility by inhibiting acetylcholinesterase activity in stomach; however, the mechanism of distribution of acotiamide from blood to stomach has not been clarified. Here, the tissue distribution of acotiamide was investigated in rats. The t