Acid phoshatase in human synovial fluid

✍ Scribed by Carol Smith; David Hamerman

• Publisher: John Wiley and Sons
• Year: 1962
• Tongue: English
• Weight: 225 KB
• Volume: 5
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780050410

✦ Synopsis

YNOVIAL MEMBRANE lining cells show acid phosphatase activity in S granules that are thought to be lysosomes.' In rheumatoid arthritis, the lining cells show markedly increased acid phosphatase activity.' This observation led us to compare acid phosphatase activity in synovial fluids from normal and arthritic joints with the thought that in rheumatoid arthritis, lysosome of lining cells might release their contained hydrolytic enzymes into synovial effusions. There appears to be no previous study of the occurrence of acid phosphatase in synovial fluid, although activities of a number of other enzymes have been measured: glucuronidase,2 pepsin and trypsin? amylase and lipase,' peroxidase,s alkaline phosphatase and transaminases8