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Acid catalyzed rearrangement of vinyl and ketene acetals

✍ Scribed by Maziarz, Elżbieta; Furman, Bartłomiej


Book ID
124138811
Publisher
Elsevier Science
Year
2014
Tongue
French
Weight
906 KB
Volume
70
Category
Article
ISSN
0040-4020

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1,3-Rearrangement of ketene-N,O-acetals
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Ketene N,O-acetals were prepared stereoselectively and submitted to a Lewis acid-mediated 1,3-rearrangement to afford C-alkylated products. The reactions proceeded in a stereoselective manner to construct a chiral quaternary carbon in high selectivity. The stereochemistry of the quaternary center wa