## Abstract A convenient one‐pot approach to the important pharmacore includes the initial reduction of the nitro group and subsequent acid‐induced rearrangement via a novel ring contraction.
Acid-catalyzed rearrangement of 3-(β-2-aminostyryl)quinoxalin-2(1H)ones—a new and efficient method for the synthesis of 2-benzimidazol-2-ylquinolines
✍ Scribed by Vakhid A. Mamedov; Dina F. Saifina; Aidar T. Gubaidullin; Venera R. Ganieva; Saniya F. Kadyrova; Dimitry V. Rakov; Il’dar Kh. Rizvanov; Oleg G. Sinyashin
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 316 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
1
H NMR data X-ray diffraction analysis a b s t r a c t A highly efficient, one-step, versatile method for the synthesis of 2-benzimidazol-2-ylquinolines has been developed on the basis of an acid-catalyzed rearrangement proceeding via a novel ring contraction of 3-(b-2-aminostyryl)quinoxalin-2(1H)ones.
📜 SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
The synthesis of new pyrrole-functionalized quinoxalines and benzimidazole is described. Our methodology involves the condensation between 2-oxo-2-(1H-pyrrol-2-yl)acetic acid and differently substituted 1,2-phenylene diamines. Depending on the substitution and on the reaction conditions, the synthes
Different thiaxolvlthiocoumarins were prepared by the reaction of (thiaxol-2-ylthio) acetic acid hydra&d& with-2hydroxybenxaldehydes, followed by cyclixation of the formed N-benzylidene derivatives in presence of PPA. A variety of coumarins 1,2 ,thiaxoles3'4 and thiazolylcoumarins 5-9 derivatives h