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Acid-Catalyzed Nucleophilic Aromatic Substitution: Experimental and Theoretical Exploration of a Multistep Mechanism

✍ Scribed by Mårten Jacobsson; Jonas Oxgaard; Carl-Olof Abrahamsson; Per-Ola Norrby; William A. Goddard III; Ulf Ellervik


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
459 KB
Volume
14
Category
Article
ISSN
0947-6539

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Highly Regioselective DABCO-Catalyzed Nu
✍ Yao-Jun Shi; Guy Humphrey; Peter E. Maligres; Robert A. Reamer; J. Michael Willi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 78 KB

## Abstract Exclusive formation of 6‐aryloxy ethers **9** from an S~N~Ar reaction of methyl 2,6‐dichloronicotinate (**2**) with phenols **7** catalyzed by 1,4‐diazabicyclo[2.2.2]octane (DABCO) in the presence of stoichiometric triethylamine is described. The reaction proceeds __via__ the regioselec