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Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia

✍ Scribed by Jubb, A M; Chalasani, S; Frantz, G D; Smits, R; Grabsch, H I; Kavi, V; Maughan, N J; Hillan, K J; Quirke, P; Koeppen, H


Book ID
110070403
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
976 KB
Volume
25
Category
Article
ISSN
0950-9232

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Members of the Wnt family of secreted glycoproteins act as short-range signaling molecules in vertebrate embryogenesis. Previous work has shown that Wnt-4 is required for kidney development. Mice lacking functional Wnt-4 fail to form pretubular cell aggregates. Wnt-4 acts as an autoinducer of the me