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Acetylcholinesterase inhibition by bis-carbamates

โœ Scribed by Ching-Chieh Yu; Clyde W. Kearns; Robert L. Metcalf; J.D. Davies


Book ID
119026523
Publisher
Elsevier Science
Year
1971
Tongue
English
Weight
532 KB
Volume
1
Category
Article
ISSN
0048-3575

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โœ Gialih Lin; Wei-Cheng Liao; Chung-Hwey Chan; Yi-Hian Wu; Hou-Jen Tsai; Chi-Wei H ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 132 KB ๐Ÿ‘ 2 views

4-Nitrophenyl-N-substituted carbamates (1) are characterized as pseudosubstrate inhibitors of acetylcholinesterase. The first step is formation of the enzyme-inhibitor tetrahedral intermediate with the inhibition constant (K i ), the second step is formation of the carbamyl enzyme with the carbamyla