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Acetylcholine-induced initiation of thymic lymphoblast DNA synthesis and proliferation

✍ Scribed by J. P. Macmanus; A. L. Boynton; J. F. Whitfield; D. J. Gillan; R. J. Isaacs

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
797 KB
Volume
85
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Low (5 × 10^−9^ M to 10^−7^ M) acetylcholine concentrations cause a calcium‐independent stimulation of the initiation of DNA synthesis and proliferation of lymphoblasts which are part of rat thymocyte populations suspended in vitro. A much higher (5 × 10^−5^ M) acetylcholine concentration also stimulates lymphoblast DNA synthesis and proliferation, but this action is calcium‐dependent. This proliferogenic response to acetylcholine is however not clearly mediated by either cyclic GMP or cyclic AMP.

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