Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart
โ Scribed by Sakmann, B.; Noma, A.; Trautwein, W.
- Book ID
- 109730910
- Publisher
- Nature Publishing Group
- Year
- 1983
- Tongue
- English
- Weight
- 434 KB
- Volume
- 303
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/303250a0
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๐ SIMILAR VOLUMES
M2-cholinergic receptor activation by acetylcholine (ACh) is known to cause a negative inotropic and chronotropic action in atrial tissues. This effect is still controversial in ventricular tissues. The ACh-sensitive muscarinic K+ channel (IK(ACh)) activity was characterized in isolated feline atria
We studied single channel ionic currents in cell-attached patches of guinea pig heart cells under conditions of anoxia (pO2 less than 0.1 torr) to identify the type of channels which contribute to the anoxia-induced time-independent K current in whole cells. In most experiments, K currents were reco