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The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

✍ Scribed by Logothetis, Diomedes E.; Kurachi, Yoshihisa; Galper, Jonas; Neer, Eva J.; Clapham, David E.


Book ID
109748164
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
685 KB
Volume
325
Category
Article
ISSN
0028-0836

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✍ Yoshihisa Kurachi; Hiroyuki Ito; Tsuneaki Sugimoto 📂 Article 📅 1990 🏛 Springer 🌐 English ⚖ 232 KB

Concentration-dependent effects of intracellular GTP on activation of the muscarinic K + channel were examined in inside-out patches of cardiac atrial myocytes. The pipette solution contained 0.i ~I ACh. GTP (0.01-30 ~M) and 0.5 mM MgCI 2 were applied to the inside side of the patch membrane. K + ch