## Abstract ## BACKGROUND. Because the investigation of epidermal growth factor receptor gene (__EGFR__) status as a predictor of gefitinib efficacy in Japanese patients has shown promise, the authors evaluated __EGFR__ mutations and gene amplification in biopsy specimens from Japanese patients wi
Accuracy of epidermal growth factor receptor mutation analysis on the basis of small biopsy specimens in patients with nonsmall cell lung cancer
β Scribed by Shiro Fujita; Tadashi Mio; Makoto Sonobe; Kiyofumi Kamiyama; Katsuhiro Masago; Ryo Miyahara; Hiromi Wada; Michiaki Mishima
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- French
- Weight
- 49 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0020-7136
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β¦ Synopsis
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## Abstract Recently, mutations in the __epidermal growth factor receptor__ (__EGFR__) gene in nonsmall cell lung cancer (NSCLC) patients were reported to correlate with gefitinib response. Less than 30% of NSCLC patients are surgically resectable; however, molecular analysis has to rely on nonsurg
## Abstract We investigated the relationships between genetic factors and clinical outcome in Japanese nonβsmallβcell lung cancer (NSCLC) patients treated with gefitinib. Ninetyβeight NSCLC patients who had been treated with gefitinib, were screened for mutations in epidermal growth factor receptor
## Abstract ## Background and Objectives In this paper we examined the influence of epidermal growth factor receptor (EGFR) gene mutations on EGFR expression, downstream mediators, and survival in patients with nonβsmall cell lung cancer (NSCLC). ## Methods We retrospectively analyzed the tumors