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Clinical significance of aberrant methylation of prostaglandin E receptor 2 (PTGER2) in nonsmall cell lung cancer : Association with prognosis, PTGER2 expression, and epidermal growth factor receptor mutation

✍ Scribed by Lei Tian; Makoto Suzuki; Takahiro Nakajima; Rieko Kubo; Yasuo Sekine; Kiyoshi Shibuya; Kenzo Hiroshima; Yukio Nakatani; Takehiko Fujisawa; Ichiro Yoshino


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
193 KB
Volume
113
Category
Article
ISSN
0008-543X

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## Abstract ## BACKGROUND. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) have demonstrated clinical benefit in patients with nonsmall cell lung cancer (NSCLC), particularly those with tumors that have EGFR‐TK domain mutations. Moreover, the EGFR and cyclooxygenase (COX)‐2