Accumulation of weak bases in relation to intralysosomal pH in cultured human skin fibroblasts
β Scribed by Marja Hollemans; Ronald Oude Elferink; G. Philip; De Groot; Anneke Strijland; Joseph M. Tager
- Book ID
- 115725089
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 696 KB
- Volume
- 643
- Category
- Article
- ISSN
- 0005-2736
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Skin fibroblasts from ataxia telangiectasia and xeroderma pigmentosum (XP) donors and from the XP sib (possible heterozygote), all genetically predisposed to a high risk of cancer, show an increased susceptibility to light-induced chromatid breaks after culture in vitro. Light-induced chromatid brea
## Abstract A metallothioneinβlike protein (MTP) is synthesized in normal diploid human skin fibroblasts cultured in Znβ or Cuβsupplemented medium. Synthesis of MTP is not detected in cells cultured without metal supplementation of complete tissueβculture medium. Cultured fibroblasts from patients