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Light-induced chromatid damage in human skin fibroblasts in culture in relation to their neoplastic potential

✍ Scribed by Ram Parshad; Raymond Gantt; Katherine K. Sanford; Gary M. Jones; Richard F. Camalier

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
597 KB
Volume
28
Category
Article
ISSN
0020-7136

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✦ Synopsis

Skin fibroblasts from ataxia telangiectasia and xeroderma pigmentosum (XP) donors and from the XP sib (possible heterozygote), all genetically predisposed to a high risk of cancer, show an increased susceptibility to light-induced chromatid breaks after culture in vitro. Light-induced chromatid breaks were shown previously to result from generation of hydrogen peroxide (H20,) during light exposure. The level of susceptibility attained is significantly higher than that observed in 13 lines of fibroblasts from normal skin of donors ranging in age from 3 days t o 92 years or from fetal skin tested at various population doubling levels. Two lines of normal skin fibroblasts transformed by chemical carcinogens to neoplastic cells also show a significant increase in susceptibility as compared with their untransformed controls.

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