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Accessory molecules for MHC class II peptide loading

✍ Scribed by Robert Busch; Robert C Doebele; Namrata S Patil; Achal Pashine; Elizabeth D Mellins

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 228 KB
Volume: 12
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(99)00057-6

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✦ Synopsis

Accessory molecules, such as HLA-DM and invariant chain, modulate the ligands bound to MHC class II molecules in antigen-presenting cells. Recent investigations, including gene targeting experiments, have shed light on the functions of these molecules, their mechanisms of action, interactions with class II molecules, and the relationships with associated molecules such as tetraspanins and HLA-DO.

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