Accessible DNA in Chromatin
โ Scribed by Ruth F. ITZHAKI
- Book ID
- 115114278
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 682 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1432-1327
No coin nor oath required. For personal study only.
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Recently, there has been a convergence of fields studying the processing of DNA, such as transcription, replication, and repair. This convergence has been centered around the packaging of DNA in chromatin. Chromatin structure affects all aspects of DNA processing because it modulates access of prote
The chromatin organization of living mammalian cells was probed using 8-methoxypsoralen (MOP). In intact cells, MOP intercalates into DNA domains which are also preferentially accessible to micrococcal nuclease. After UV365 nm irradiation of MOP-treated cells, this chemical forms bifunctional adduct