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Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors

✍ Scribed by Jing, Qing; Li, Huiying; Roman, Linda J.; Martásek, Pavel; Poulos, Thomas L.; Silverman, Richard B.

Book ID
121414173
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
1021 KB
Volume
5
Category
Article
ISSN
1948-5875

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## Abstract Utilization of nitric oxide (NO) synthase (NOS) inhibitors to probe the role of NO in various central nervous system processes requires use of an inhibitor selective for neuronal NOS, and is facilitated by knowledge of the pharmacokinetics of the inhibitor. The present project was under