Accessibility of N-acyl-d-mannosamines to N-acetyl-d-neuraminic acid aldolase
โ Scribed by Yanbin Pan; Tiffany Ayani; Janos Nadas; Shouming Wen; Zhongwu Guo
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 400 KB
- Volume
- 339
- Category
- Article
- ISSN
- 0008-6215
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๐ SIMILAR VOLUMES
been reported previously (24). The methods seem appropriate for estimates of transdermal absorption if a specific analytical procedure is not available and percutaneous first-pass metabolism is not extensive.
N-Acetylneuraminic acid (1) can be transformed into the methyl a-u-ketoside 2 which, by reaction with methanesulfonyl chloride, yields the corresponding 4-0 mesylate 3 and the 4.7-di-0 -mesylate 4 as a by-product. Compound 3 reacts with Nal giving the 4-dcoxy-4-iodo compound 5 with cquatorial orient
Aldol condensation of la with potassium di-tert-butyloxaloacetate yields the two epimeric 6-thiosialic acids 2 and 3. As opposed to this, reaction between thiofuranose 6 \_ and nickel (II)/oxaloacetate affords 6-thio-N-acetyl-D-neuraminic acid \_Ic. Substituting sulfur for oxygen in the pyranosering