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Accessibility of N-acyl-d-mannosamines to N-acetyl-d-neuraminic acid aldolase

โœ Scribed by Yanbin Pan; Tiffany Ayani; Janos Nadas; Shouming Wen; Zhongwu Guo


Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
400 KB
Volume
339
Category
Article
ISSN
0008-6215

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๐Ÿ“œ SIMILAR VOLUMES


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been reported previously (24). The methods seem appropriate for estimates of transdermal absorption if a specific analytical procedure is not available and percutaneous first-pass metabolism is not extensive.

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N-Acetylneuraminic acid (1) can be transformed into the methyl a-u-ketoside 2 which, by reaction with methanesulfonyl chloride, yields the corresponding 4-0 mesylate 3 and the 4.7-di-0 -mesylate 4 as a by-product. Compound 3 reacts with Nal giving the 4-dcoxy-4-iodo compound 5 with cquatorial orient

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โœ H Mack; R Brossmer ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 224 KB

Aldol condensation of la with potassium di-tert-butyloxaloacetate yields the two epimeric 6-thiosialic acids 2 and 3. As opposed to this, reaction between thiofuranose 6 \_ and nickel (II)/oxaloacetate affords 6-thio-N-acetyl-D-neuraminic acid \_Ic. Substituting sulfur for oxygen in the pyranosering