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Genome-wide association studies that use univariate tests are efficient to identify the variants involved in diseases. However, these tests cannot detect recessive effects, especially when the genetic variants involved are rare. Instead of looking at one marker at a time, recent works propose to detect tracts of homozygosity associated to the disease status. A novel method, implemented in the program WHAMM (Whole-Genome Homozygosity Analysis and Mapping Machina, http://www.broadinstitute.org/$bvoight/whamm/), estimates the Identity by Descent (IBD) status of each individual and compares the distribution of autozygosity between cases and controls. To estimate the IBD status by
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## Abstract Author Index and Keyword Index are included, following abstracts.
Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis Related Traits Yi-Hsiang Hsu (1), M. Carola Zillikens (2), Scott G. Wilson (3), Charles R. Farber (4), Serkalem Demissie (5), Estelle N. Bianchi (6), L
This study examined the association between bone mineral density (BMD) and a T/C polymorphism in the first of two start (ATG) codons in the vitamin D receptor (VDR) gene. The polymorphism was detected using the restriction enzyme FokI, the F allele indicating absence of the first ATG and the f allel