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Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis Related Traits Yi-Hsiang Hsu (1), M. Carola Zillikens (2), Scott G. Wilson (3), Charles R. Farber (4), Serkalem Demissie (5), Estelle N. Bianchi (6), Liming Liang (7), J. Brent Richards (8), Karol Estrada (2), Yanhua Zhou (5), Nicole Soranzo (9), Atila van Nas (10), Miriam F. Moffatt (11), Guangju Zhai (12), Albert Hofman (13), Joyce B. van Meurs (2), Roger I. Price (3), L. Adrienne Cupples (5), Aldons J. Lusis ( 14), Eric E. Schadt (15), Serge Ferrari (6), Andre ยดG. Uitterlinden (2), Fernando Rivadeneira (2), Tim D. Spector (12), David Karasik (1), Douglas P. Kiel (1)
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## Abstract Author Index and Keyword Index are included, following abstracts.
Genome-wide association studies that use univariate tests are efficient to identify the variants involved in diseases. However, these tests cannot detect recessive effects, especially when the genetic variants involved are rare. Instead of looking at one marker at a time, recent works propose to det
This study examined the association between bone mineral density (BMD) and a T/C polymorphism in the first of two start (ATG) codons in the vitamin D receptor (VDR) gene. The polymorphism was detected using the restriction enzyme FokI, the F allele indicating absence of the first ATG and the f allel